Denis O'Donnell M.D., FRCP(C), FCCP

Denis O'Donnell
  • Professor
  • 102 Stuart Street
  • Kingston, Ontario
  • K7L 3N6
  • Telephone: 613-548-2339
  • Fax: 613-549-1459
  • E-Mail:

Faculty Bio

Denis E. O’Donnell, MB, BCh., (NUI), MD (NUI), FRCP(I), FRCP(C) is a Professor of Medicine, with cross appointments to the Departments of Biomedical & Molecular Sciences (Physiology), Rehabilitation Medicine and Kinesiology & Health Studies, Queen’s University, Kingston, Ontario, Canada.  He is a Clinician Scientist and past Chair of the Division of Respiratory and Critical Care Medicine and Director of the Respiratory Investigation Unit at Queen’s.  He completed clinical research fellowships in Respirology at TrinityCollege, Dublin, and at the University of Manitoba (1984-1988), where he completed a doctoral thesis in medicine on the topic “Mechanisms of Dyspnea in COPD” in 1988.  Dr. O’Donnell’s main research focus is clinical integrative physiology and specifically, exercise pathophysiology and mechanisms and management of dyspnea in respiratory disorders.  His main clinical focus is COPD and pulmonary rehabilitation.

Dr. O’Donnell had a leadership role (Chair) in the development of best practice guidelines for the management of COPD in Canada.  He has been a senior author in over 260 scientific publications.  He has co-edited a book on Dyspnea, now in its third edition.  He has lectured extensively on these topics both at a national and international level. 

He has been the recipient of the Basmajian award for Excellence in Biomedical research at Queen’s University.  He held a Career Scientist Award from the Ontario Ministry of Health from 1994 to 2004.  He gave the American College of Chest Physicians Distinguished Scientist Honour Lecture in 2005, the Trudeau Lecture for the New York Thoracic Society in 2007, the Jean Jacques Gauthier Award and Honour Lecture, University of Montreal and the John Rankin Visiting Professor and Honour Lecture, University of Madison, Wisconsin in 2008.  In 2012 he received an award for Excellence in Research in Respiratory Physiology by the Association for Respiratory Technology & Physiology (ARTP) in the United Kingdom.

He serves on several national and international scientific panels on respiratory diseases and sits on the Editorial Boards for CHEST, Journal of Applied Physiology, Journal of COPD, the International Journal of COPD, and is an Associate Editor of the Canadian Respiratory Journal.  He is the Past President of the Canadian Thoracic Society and is a member of the Institute Advisory Board (IAB) for the Canadian Institutes of Health Research (Circulatory and Respiratory Health).   He is currently the National Canadian Delegate for the European Respiratory Society. 

102 Stuart Street,
Kingston, ON 
K7L 3N6
Phone: 613.548.2339
Fax: 613.549.1459
Clinical Interests:
General Respirology
Pulmonary Rehabilitation 

Clinical Appointments:
G.F.T. Kingston General Hospital
Consultant: Hotel Dieu Hospital
Providence Continuing Care, St. Mary's on the Lake

Academic Interests:
Director, Respiratoru investigation Unit
Queen's University
Exercise physiology
Control of breathing in cardiopulmonary disease
Lung mechanics in COPD
Mechanisms and management of dyspnea in
cardriopulmonary disease

Administrative Appointments:
Professor, Department of Medicine
Professor, Department of Physical Medicine and 
Professor, Department of Physiology
Professor, School of Kinesiology and Health Studies

Selected Publications:

O'Donnell DE, Webb K. Exertional breathlessness in patients with chronic airflow limitation: the role of lung hyperinflation. Am Rev Respir Dis 1993: 48(5):1351-1357.

Loughneed MD, Webb K, O'Donnell DE. Breathlessness during induced hyperinflation in asthma: the role of the inpiratory threshold load. Am J Respir Crit Care Med 1995; 152(3):911-920.

O'Donnell DE, Bertley J, Webb KA, Conian AA. Mechanisms of relief of extertional breathlessness following unilateral bullectomy and lung volume reducation surgery in advanced chronic airflow limitation. Chest, 1996; llo: 18-27. 

O'Donnell DE, Chau LL, Bertley J, Webb KA. Qualitative aspects of exertional breathlessness in chronic airflow limition: pathophysiological mechanisms.
Am J Respir Crit Care Med 1997: 155:190-115.

O'Donnell DE, Chau LKL, Webb KA. Qualitative aspects of exertional dyspnea in interstitial lund disease. J Appl  Physiol 1998; 84: 2000-2009.

O'Donnell DE, McGuire M, Samis L, Webb KA. Effects of general exercise training on ventilatory and peripheral muscle strength and endurance in chronic airflow limitation.
Am J Respor Crit Care Med 1998: 157:1489-1497.

O'Donnell DE, Lam M, Webb KA. Measurement of exertional symptoms, dynamic hyperinflation and exercise endurance in COPD. 
Am J Respir Crit Care Med 1998;158:1557-1565.

O'Donnell DE, D'Arsigny C, Raj S, Abdollah, Webb KA. Ventilatory assistance improves exercise endurance in patients with stable congestive heart failure.
Am J Respir Crit Care Med 1999;160:1804-1811.

O'Donnell DE, Hong HH, Webb KA. Effects of chest wall restriction and deadspace loading on dyspnea and exercise tolerance in healthy normals. J Appl Physiol 2000;88:1859-1869.

O'Donnell DE, Revill SK, Webb KA. Dynamic hyperinflation and exercise intolerance in COPD.
Am J Respir Crit Care Med 2001:164:770-777.

Lougheed MD, Flannery J, Webb KA, O'Donnell DE. Respiratory sensation and ventilatory mechanics during induced bronchoconstriction in spontaneously breathing low cervical quadriplegia.
Am J Respit Crit Care Med 2001;166:370-376.

O'Donnell DE, D'Arsigney C, Fitzpatrick M, Webb Ka. Exerice hypercapnia in advanced COPD: the role of lung hyperinflation.
Am J Respir Crit Care Med 2002:166:663-668 [with accompanying editorial]

O'Donnell DE, Voduc N, Fitzpatrick M, Webb KA. Effect of salmeterol on the ventilatory response to exercise in COPD. 
Eur Respir 2004;24:86-94.

O'Donnell D, Fluge T, Gerken F, Hamilton A, Webb K, Agauilaniu B, Make B, Magnussen H. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD.
Eur Respir J 2004; 23:832-840.

Jensen D, Wolfe La, Slatkovska L, Webb KA, Davies GAL, O'Donnell DE. Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide. Am J Physiol: Regulatory, integrative and Comparative Physiology 2005;288:1369-1375.

Parker CM, Voduc N, Aaron SD, Webb KA, O'Donnell DE. Physiological changes during symptom recovery from moderate exacerbation of COPD. Eur Respir J 2005;26(3):420-428. [with accompanying editorial]

Peters MM, Webb KA, O'DonnellDE. Combined physiological effects of bronchodilators and hyperoxia on dyspnea and exercise performance in normoxiz COPD.
Thorax 2006;61:559-567. [with accompanying editorial]

O'Donnell DE, Hamilton AL, Webb KA. Sensory-mechanical relationship during high intensity, contant work rate exercise in COPD.
J Appl Physiol 2006;101:1025-1035. [with accompanying editorial]

O'Donnell DE, Banzett RB, Carrieri-Kohlman V, Casaburi R, Davenport PW, Gandevia SC, Gelb AF, Mahler DA, Webb KA. Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc Am Thorac Soc 2007;4:145-168.

Ofir D, Laveneziana P, Webb KA, O'Donnell DE. Ventilatory and perceptual responses to cycle exercise in obese women. J Appl Physiol 2007; 102:2217-2226. [with accompanying editorial]

Travers J, Dudgeon DJ, Amjadi K, MacBride I, Dillon K, Lavenziana P, Ofir D, Webb Ka, O'Donnell DE.
Mechanisms of exertional dyspnea in patients with cancer.
J Appl Physiol 2007 Nov 1; Epub ahead of print as doi: 10.1152/japplphysiol.00653.2007.

Ofir D, Laveneziana P, Webb KA, Lam Y-M, O'Donnell DE. Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage |COPD
Am J Respir Crit Care Med 2007 Nov 15; Epub ahead of print as doi:10.1164/rccm.200707-1064OC.
Guidelines and Task Force Summaries:

Meek P, Schwartzstein RM, Adams L, Altose MD, Breslin EH, Carrieri-Kohlman V, Gift A, Hanley MV, Harver A, Jones PW, Killian K, Knebel A, Lareau SC, Mahler DA, O'Donnell DE, Steele D, Stuhlbarg M, Titler M; an ATS ad committee. Dyspnea: mechanisms, assessment and management: a consensus statement. Am J Respir Crit Care 1999;159:321-340.

Banzett RB, Dempsey JA,  O'Donnell DE, Wambolt MZ; NHLBI Workshop Summary. Symptom perception and respiratory sensation in asthma. Am J Respir Crit Care Med 2000;162:1178-1182.

O'Donnell DE, Aaron S, Bourbeau J, et al. Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease. Can Respir J 2003;10(Suppl A):11A-33A.

Nici L, Donner C, Wouters E, Zuwallack R, Abrosino N, Bourbeau J, Carone M, Celli B, O'Donnell D, et all; on behalf of the ATS/ERS pulmonary rehabilitation writing committee American Thoracic Society/European Respiratory Society statement of pulmonary rehabiliation. Am J Respir Crit Care Med 2006;173:1390-1413.

ERS Task Force; Palange P, Ward SA, Carlsen K-H, Casaburi, Gallagher CG, Gosselink R, Puente-Maestu, O'DonnellDE, Schols AM, Sing S,Whipp BJ. Recommendations on the use of exercise testing in clinical practive. Eur Respir J 2007;29:185-209.

O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, MarciniukDD, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan S, Lacasse Y, Maltais F, Road J, Rocker G, Rocker G, Sin D, Sinuff T, Voduc N,
Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. 
Can Respir J 2007;14(Supple B): 5B-32B.

Last Modified: 2018-01-25