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Katie Lindale

Wed, 02/23/2022 - 22:15

Thanks for the fantastic summary Pierce! Dr. Bai's discussion was thoroughly enjoyable and enlightening. I found the discussion on intention to treat (ITT) analysis particularly interesting, considering its utility in managing noncompliance and its inherent shortcomings in assessing treatment efficacy (1). I'm intrigued by the idea of taking ITT analysis' utility a step further and identifying patterns in study participants who end up with changes in their planned treatment course after randomization. From a translational lens, protocol-deviating real-world clinical data can be as informative as it is complicated. Especially in the world of Infectious Disease research, learning about how patients fare on treatments and adapt course could highlight important research areas otherwise overlooked in the search for highly effective therapeutics. I'm curious to know what the class thinks about the pros and cons of using ITT analysis, and what our responsibilities are as translational researchers in capturing patterns in the real-world data that this strategy can provide us with.

Many thanks,


(1) Gupta SK. Intention-to-treat concept: a review. Perspectives in clinical research. 2011 Jul;2(3):109.

Katie Lindale

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