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Kiera Liblik

Tue, 11/16/2021 - 09:58

Dear Kyla,
Thank you for an excellent summary and discussion of last week's MGR. It seems that perioperative atrial fibrillation (AF) is gaining a lot of attention as of late, given the associated long-term morbidity and mortality (1-4). A recent review on the topic highlighted that age may play a role, as atrial fibrosis becomes more common with time (5). I wonder that if with enough information, we could better predict perioperative AF and, in turn, attempt to prevent it by administering anti-arrhythmic agents in the time leading up to surgery. Perhaps this could be used in conjunction with colchicine. Although, if the COP-AF trial is successful we may not need to look further!
Warm regards,

1. Conen, D., Wang, M. K., Devereaux, P. J., Whitlock, R., McIntyre, W. F., Healey, J. S., ... & Lamy, A. (2021). New‐Onset Perioperative Atrial Fibrillation After Coronary Artery Bypass Grafting and Long‐Term Risk of Adverse Events: An Analysis From the CORONARY Trial. Journal of the American Heart Association, e020426.
2. Conen, D., Alonso-Coello, P., Douketis, J., Chan, M. T., Kurz, A., Sigamani, A., ... & Devereaux, P. J. (2020). Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery. European heart journal, 41(5), 645-651.
3. Subramani, Y., El Tohamy, O., Jalali, D., Nagappa, M., Yang, H., & Fayad, A. (2021). Incidence, Risk Factors, and Outcomes of Perioperative Atrial Fibrillation following Noncardiothoracic Surgery: A Systematic Review and Meta-Regression Analysis of Observational Studies. Anesthesiology research and practice, 2021.
4. Wang, M. K., Meyre, P. B., Heo, R., Devereaux, P. J., Birchenough, L., Whitlock, R., ... & Conen, D. (2021). Short-term and long-term risk of stroke in patients with perioperative atrial fibrillation after cardiac surgery: Systematic review and meta-analysis. CJC Open.
5. Karamchandani, K., Khanna, A. K., Bose, S., Fernando, R. J., & Walkey, A. J. (2020). Atrial fibrillation: current evidence and management strategies during the perioperative period. Anesthesia & Analgesia, 130(1), 2-13.

Kiera Liblik

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