This Month's TIME Showcase-Recent Publication by Dr. Paula James & Colleagues
A transcriptome analysis of basal and stimulated VWF release from endothelial cells derived from type 1 VWD patients
Robbie Kloosterman, Matteo Zago-Schmitt, Julie Grabell, Lisa Ann Thibeault, Patricia D.A. Lima, Mackenzie L Bowman, Kathrin Tyryshkin, Charles C. T. Hindmarch, Neil Renwick, Paula D. James
Journal: Blood Advances, Published-September 2022.
This research team, which includes Drs. James, Hindmarch, Renwick, and Tyryshkin successfully received an Inaugural TIME Incubator Grant worth $75K to support a project focused on understanding the transcriptional characterization of the response of endothelial cells from patients with Type 1 von Willebrand disease and normal controls to stimulation with a secretagogue. This work was the primary focus of the thesis research carried out by MSc student Robbie Kloosterman, who successfully defended his degree in April of 2021. This is an excellent example of how a multidisciplinary translational research team can use TIME incubator grants to convert dollars into data!