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QCPU Room 1605
Laboratory Scientists: Dr. Charlie Hindmarch
Whether investigating therapeutic response in a human subject or a mouse model of disease, getting the most information from every precious sample is a priority in clinical and research studies alike. Mass cytometry with Helios™ uses CyTOF® technology to enable deep profiling of translational and clinical research samples across a range of cell surface and intracellular markers. Designed to significantly reduce signal overlap, mass cytometry empowers researchers to simultaneously interrogate cellular phenotypes, function and signaling status in higher dimension than traditional fluorescence methods.
The Hyperion Imaging System brings proven CyTOF® technology together with imaging capability to empower simultanous interrogation of 4 to 37 protein markers using Imaging Mass Cytometry™ (IMC™). Using this system, you can deeply interrogate tissues and tumors at subcellular resolution while preserving the information in tissue architecture and cellular morphology to uncover new biomarker correlations and cell interactions. Ability to utilize up to 135 channels to detect additional parameters.
The MultiPep RSi is an automated high-throughput parallel peptide synthesizer based on a pipetting robot operated by a dedicated PC-Software. Exchangeable modules allow to configure the MultiPep RSi as a 5-in-1 synthesizer that enables the synthesis of hundreds of peptides in one run. Switching from one module to another is done in a couple of minutes. Up to 7 solvent positions and 13 additional reagent bottles offer the flexibility to run complex chemistry protocols.
Available modules:
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- Column Module: large scale, up to 48 or 72 peptides at a scale of up to 500 µmol
- Plate Module: small scale; up to 384 (4x 96) peptides at 1-10 µmol
The synthesis is performed in plates or in disposable columns containing derivatized resin. Alternatively, for large screening projects, hundreds of peptides can be synthesized on membranes (SPOT method) or on individual dissolvable discs for CelluSpots™ production (peptide arrays on coated microscope slides).
The instrument covers the requirements of core facilities, research laboratories and custom synthesis houses. Switching from one module to another is done in a couple of minutes. Up to 7 solvent positions and 13 additional reagent bottles offer the flexibility to run complex chemistry protocols.
Available modules:
- SPOT Module: automated SPOT synthesis of peptide arrays on up to four membranes (up to 600 peptides on each)
- CelluSpots™ Module: synthesis for CelluSpots™ peptide arrays
