Dr. Archer's Lab | Department of Medicine | School of Medicine

Trainees
Danchen Wu Post-doctoral Fellow danchen.wu@queensu.ca Biosketch	Danchen’s research focuses on elucidating the role of mitochondria motility in pathogenesis of pulmonary arterial hypertension (PAH). This study will find out how mitochondria motility is changed in PAH and how it is interacting mitochondria fusion and fission. Danchen is also interested in exploring the effects of potential Drp1 inhibitors on mitochondria fission, which may serve as therapeutics for PAH and cancers in future.

Staff
Kuang-Hueih Chen Research Associate kuanghueih.chen@queensu.ca Biosketch	Kuang-Hueih's research focuses on determining the role of Drp-1 binding partners MiD49 and MiD51 in the pathogenesis of proliferative diseases such as cancers and pulmonary arterial hypertension (PAH). This study will establish how the expression of Drp1 binding partners changes (and varies) in proliferative diseases and may also identify potential therapeutic targets for cancers and PAH.
Asish Das Gupta Research Associate asish.dasgupta@queensu.ca Biosketch	Asish's research concentrates on elucidating the role of phosphorylation-induced degradation of Mitofusin 2 (Mfn2) in proliferative diseases such as cancers and pulmonary arterial hypertension (PAH). This study will explore the possibility of utilizing phosphorylation-resistant mutant isoform of Mfn2 by adenoviral mediated gene transfer as a novel therapy for cancers and PAH.
Ashley Martin Research Assistant a.martin@queensu.ca	Ashley is responsible for assisting in Archer Lab research, including animal care, surgical procedures, Langendorff, data collection, tissue harvest/sample collection, and cell culture. Ashley also manages the mouse colony, maintains inventory of biohazard material and lab supplies, purchases lab supplies, and assists in managing lab finances, including procurement reconciliation.
Jeff Mewburn Research Associate/Imaging Specialist mewburnj@queensu.ca	Responsible for the operations of the imaging facilities and the laboratory's IT needs. His expertise include: Super Resolution Microscopy Live-cell resonant scanning to study mitochondrial dynamics Confocal microscopy 2-photon microscopy Flow cytometry Experiments involving TIRF, FRET, FRAP, photo activation, live cell imaging, three-dimensional reconstruction and analysis Intravital work on a spinning disk confocal platform studying murine liver, lung, spleen, lymph node and tumor models Intravital video microscopy, performing hemodynamic experiments in live tissues